Copper Peptides in Skin Care Solutions
In snail organism cells, glycosaminoglycans (GAGs) are mainly located inside granules and in the shell, and are produced on the exterior of the shell as a mucous-like liquid. Snail glycosaminoglycan tightly unites divalent copper cations (Cu 2 ) that form copper peptides. This substance reportedly has skin regeneration properties. The proportion of copper in the snail mucins is impressive.
Copper peptides have been demonstrated to be active in just small quantities:
Copper-induced vascular endothelial growth factor expression and wound healing. Sen CK, Khanna S, Venojarvi M, Trikha P, Ellison EC, Hunt TK, Roy S. 2002 May;282(5):H1821-7.
Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart & Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
Angiogenesis, the formation of new blood vessels, plays a central role in wound curing. Among many recognized growth factors, the vascular endothelial growth factor (VEGF) is believed to be the most prevailing, efficient, and long-term signal that is recognized to promote angiogenesis in injuries. Whereas the active role of copper in promoting angiogenesis has been evident for the past 20 years, the specific targets of copper action remained unclear.
This paper includes initial findings, showing that inducible VEGF expression is sensitive to copper production, and that the angiogenic potential of copper can be harnessed to accelerate dermal wound contraction and closure.
In relatively normal concentrations, copper sulfate induced VEGF expression has be proven to mutate human keratinocytes. Copper used some of the pathways utilized by hypoxia to regulate VEGF expression. Topical copper sulfate speeded up the closure of excisional murine dermal injuries, permitting lesions to heal by secondary intention. Copper-sensitive pathways regulate key mediators of wound healing, such as angiogenesis and extracellular matrix rejuvenating.
Copper-based therapeutics represents a feasible approach to stimulate dermal wound healing, including it among the likely components of natural skin care treatments.
Some kinds of copper peptide complexes possess both tissue protection and repairing abilities. Copper has defensive and rejuvenative actions on several organ systems includingbone, hair follicles,gastric mucosa, skin and intestinal linings. These kinds of copper complexes are increasingly used in cosmetic skin and hair care products because of their ability to trigger the regeneration of skin. You will find them among other dermatological skin rejuvenating procedures, such as chemical peels, laser resurfacing and dermabrasion, to enhance post-treatment skin recovery.
The main interest in copper peptides is in the area of retarding the effects of human aging and ultraviolet damage of the human skin. During the aging process, skin becomes thinner and tends to accumulate various skin lesions and blemishes. Within the dermis and epidermis, thin and subcutaneous fat cells decrease in number.
Several studies have found that the application of copper peptide creams to the human skin is even more efficient in promoting collagen production than retinoic acid or vitamin C. It also increases the thickness of the epidermis and dermis, increases cellular regeneration, reduces wrinkles and eliminates skin blemishes such as blotchiness and sun damage marks.
A new sensitive skin care solution is the latest answer for all your dermal problems, including scars and imperfections. Biological ingredients ensure a safe and promising skin rejuvenation process.
Published March 7th, 2008